Contribution of Biological and EPR Dosimetry to the Medical Management Support of Acute Radiation Health Effects

Abstract In this review, we discuss the value of biological dosimetry and electron paramagnetic resonance (EPR) spectroscopy in medical management support acute radiation syndrome (ARS). Medical an ionizing scenario requires significant information. For optimal aid, information has to be rapidly (< 3 days) delivered health-care provider. Clinical symptoms may initially enable physicians predict ARS initiate respective treatment. However, most cases at least further verification through knowledge on exposure details is necessary. This can assessed by retrospective techniques, if it not directly registered personal dosimeters. The characteristics potential using human-derived specimen are presented here. Both methods discussed a clinical perspective regarding diagnostics. techniques used parallel increase screening capacity case mass casualties, as both detect critical dose 2 Gy (whole body single dose), where hospitalization will considered. Hereby, based analysis molecular biomarkers, especially gene expression analysis, but also vivo EPR represent very promising tools for rapid triage early-phase high sample throughput point-of-care diagnosis. higher or small-scale radiological incidents, complementarily understand important exposure. employed estimate whole dose, while nails, bone teeth determine partial doses. A comprehensive assessment optimization Ultimately, multipath approaches always recommended. By tapping full all diagnostic dosimetric methods, effective treatment patients supported upon radiation.